45 articles - From Friday Jul 22 2022 to Friday Jul 29 2022
Guidelines, position statements, white papers, technical reviews, consensus statements, etc…
meta-analyses and systematic reviews
RCT, clinical trials, retrospective studies, etc…
| Ann Rheum Dis |
Gain-of-function mutations in ALPK1 cause an NF- Objectives To test the hypothesis that ROSAH (retinal dystrophy, optic nerve oedema, splenomegaly, anhidrosis and headache) syndrome, caused by dominant mutation in and some features of disease are amenable to immunomodulatory therapy. |
Immunogenicity induced by two and three doses of the BNT162b2 mRNA vaccine in patients with autoimmune inflammatory rheumatic diseases and immunocompetent controls: a longitudinal multicentre study. The two-dose BNTb262 regimen was associated with similar clinical efficacy and similar waning of the humoral response over 6 months among patients with AIIRD and controls. The third vaccine dose restored the humoral response in al of the controls and the majority of patients. |
SARS-CoV-2 Omicron escapes mRNA vaccine booster-induced antibody neutralisation in patients with autoimmune rheumatic diseases: an observational cohort study. Striking antibody evasion manifested by the Omicron variant in patients with ARDs and current vaccine-induced immunity may not confer broad protection from Omicron breakthrough infection, highlighting the need for further research on vaccine effectiveness in patients with immune dysfunctions. |
| Arthritis Care Res (Hoboken) |
Do patients with intersectional disadvantage have poorer outcomes from osteoarthritis management programmes? A tapered-balancing study of patient outcomes from the Good Life with osteoArthritis in Denmark (GLA:D®) programme. Outcome inequalities widened following OAMP attendance, particularly at longer-term follow-up but the magnitude of differences was generally modest and inconsistent across outcome measures. Tailoring content to reduce outcome inequalities may be indicated but improving access appears the greater priority. |
How do non-surgical interventions improve pain and physical function in people with osteoarthritis? A scoping review of mediation analysis studies. In knee OA, some evidence suggests that the benefits of i) diet and exercise are mediated through changes in body weight, systemic inflammation and self-efficacy; ii) exercise is mediated through changes in knee muscle strength and self-efficacy; and iii) high-expectation communication style is mediated through changes in self-efficacy. |
How does job insecurity and workplace activity limitations relate to rheumatic disease symptom trajectories in young adulthood? A longitudinal study. Workplace activity limitations and job insecurity represent working conditions that are associated with the health of young adults with rheumatic disease and should be examined as potential targets for intervention. |
Predictors of pain reduction among fibromyalgia patients using medical cannabis: a long-term prospective cohort study. Our findings provide preliminary insights into the potential mechanisms of action underlying pain reductions among FM patients who are using medical cannabis. Given the high attrition rate (i.e., 75 %) observed in the present study at 12 months, our findings cannot be generalized to al FM patients who are using medical cannabis. |
Rheumatoid arthritis disease activity and hospitalized infection in a large U.S. registry. The risk of hospitalized infection was higher for RA patients in low or moderate disease activity compared to those in remission after accounting for the interplay of disease activity, RA treatments, treatment switching, and other potential confounders. |
| Arthritis Res Ther |
Investigation of the association between coffee and risk of RA-results from the Swedish EIRA study. The findings from this large, population-based case-control study did not support a significant association between coffee consumption and risk of RA as a whole nor within different subgroups. |
Oral dextran sulfate sodium administration induces peripheral spondyloarthritis features in SKG mice accompanied by intestinal bacterial translocation and systemic Th1 and Th17 cell activation. Oral DSS administration alone elicited peripheral enthesitis in SKG mice with bacterial translocation accompanied by increased splenic Th1 and Th17 cell levels. Pre-administration of antibiotics ameliorated these DSS-induced SpA features. These findings suggest that intestinal bacterial leakage plays a pivotal role in SpA pathogenesis. |
Prognostic meaning of right ventricular function and output reserve in patients with systemic sclerosis. This study demonstrates that assessment of RV function at rest and during exercise may provide crucial information to identify SSc patients who are at a high risk of poor outcome and for the development of PH and/or PVD. |
Xanthine oxidase inhibitor urate-lowering therapy titration to target decreases serum free fatty acids in gout and suppresses lipolysis by adipocytes. Metabolomic profiles linked xanthine oxidase inhibitor-based ULT titration to target with reduced serum free fatty acids. In vitro validation studies revealed that febuxostat, but not colchicine, reduced lipolysis in cultured adipocytes. Since soluble urate, xanthine oxidase inhibitor treatment, and free fatty acids modulate inflammation, our findings suggest that by suppressing lipolysis, ULT could regulate inflammation in gout and comorbid metabolic and cardiovascular disease. |
| Arthritis Rheumatol |
Subsets of Idiopathic Inflammatory Myositis Enriched for Contemporaneous Cancer Relative to the General Population. In a tertiary referral center population, anti-TIF1 |
| Rheumatology (Oxford) |
A Phase 2 trial investigating the effects of the angiotensin II type 2 receptor agonist C21 in systemic sclerosis-related Raynaud's. Despite the small trial size, a signal emerged suggesting that even in patients with established SSc, C21 may confer benefit for RP and deserves further investigation. |
Activation of circulating monocytes by low-density lipoprotein a risk factor for Osteoarthritis? The concept of innate immune training has been widely studied and implicated in atherosclerosis pathology, but its involvement in OA remains uncharted territory. Finally, we evaluate the implications of al this for targeted therapy directed to macrophages and metabolic factors. |
Association between psoriatic disease and lifestyle factors and comorbidities: cross-sectional analysis and Mendelian randomisation. Observational and genetic evidence converge to suggest that BMI and glycaemic control are associated with increased psoriatic disease risk, while psoriatic disease is associated with increased CAD risk. Further research is needed to understand the mechanism of these associations. |
COVID-19 vaccine affects neither prothrombotic antibody profile nor thrombosis in primary antiphospholipid syndrome: a prospective study. Inactivated SARS-CoV-2 vaccine does not influence the profile of antiphospholipid antibodies and anti-PF4-heparin antibodies nor induces thrombotic events in primary APS patients. |
Evaluating the value of superoxide dismutase in anti-MDA5-positive dermatomyositis associated with interstitial lung disease. In patients with anti-MDA5-positive DM, (1) the low SOD level before treatment indicated the presence of oxidative stress in the disease; (2) the serum SOD level was affected by anti-Ro-52 antibodies and ferritin; (3) there is a close relationship between serum SOD level and ILD among patients with anti-MDA5-positive DM, suggesting that SOD might serve as an effective indicator to evaluate the changes in ILD in these patients; and (4) the low SOD level is an important indicator of poor prognosis in these patients, which deserves attention from rheumatologists. |
FLT3 functional low-frequency variant rs76428106-C is associated with susceptibility to systemic sclerosis. This study is the first to report an association between rs76428176-C and SSc. Our results support the role of FLT3 as a relevant gene in seropositive immune mediated diseases and a potential biomarker for SSc microangiopathy. |
Longitudinal changes in nailfold video capillaroscopy findings differ by myositis-specific autoantibody in idiopathic inflammatory myopathy. The results of this study demonstrate that longitudinal changes in NVC findings may vary depending on myositis-specific Ab expression. Therefore, it is crucial to assess individual NVC findings separately, since each finding may impact disease activity in a different manner. |
Lupus myocarditis: review of current diagnostic modalities and their application in clinical practice. Both echocardiography as well as CMR may detect subclinical myocardial dysfunction and/or injury of which the clinical significance remains uncertain. Considering these challenges, a combined decision-making approach by rheumatologist and cardiologist, interpreting diagnostic test results within the clinical context of the patient is essential to ensure an accurate, early diagnosis of LM. |
Macrophages as determinants and regulators of fibrosis in systemic sclerosis. Subsequently, we link the activation of macrophages and monocytes to the molecular pathology of SSc, and illustrate the interplay between macrophages and fibroblasts. Finally, we present recent/near-future clinical trials and discuss novel targets related to macrophages/monocytes activation in SSc. |
PET/CT of cranial arteries for a sensitive diagnosis of giant cell arteritis. Cranial PET/CT can be easily combined with extracranial PET/CT with a limited increase in examination time. Combined cranial and extracranial PET/CT showed very high diagnostic accuracy for the diagnosis of GCA. |
Predictors and prognostic stratification for lupus low disease activity state: Results from a prospective clinical trial. Renal involvement, hematological involvement and hypocomplementemia were negative predictors of LLDAS achievement and maintenance. LLDAS-3mo was a positive predictor for the long-term sustainment of LLDAS. |
Prevalence of non-celiac gluten sensitivity and assessment of the response to gluten-free diet in a cohort of patients with fibromyalgia. A NCGS prevalence similar to that estimated in the general population was found. A GFD cannot be systematically recommended to al patients with Fibromyalgia, although it could be evaluated in those with diarrhea or intraepithelial lymphocytosis to evaluate if there are improvements in their intestinal symptoms. |
Reduced Cathepsin L Expression and Secretion into the Extracellular Milieu Contribute to Lung Fibrosis in Systemic Sclerosis. Our findings identify CTSL as a protein protective against lung fibrosis via its activation of antifibrotic ES, and whose expression in SSc pLFs and lung tissues is suppressed. Identifying strategies to boost CTSL endogenous levels in SSc patients could serve as a viable therapeutic strategy. |
Sicca syndrome in systemic sclerosis: a narrative review on a neglected issue. Sicca syndrome can occur in the absence of overlap with Sjogren disease and recent studies highlight that fibrosis of minor and major salivary glands, directly linked to the pathogenesis of SSc, could be a major contributor of xerostomia in SSc. This narrative review provides an overview of the clinical presentation, diagnostic strategies, management and future perspectives on sicca syndrome in patients with SSc. |
Soluble guanylate cyclase stimulation fosters angiogenesis and blunts myofibroblast-like features of systemic sclerosis endothelial cells. These findings demonstrate for the first time that pharmacological sGC stimulation effectively ameliorates the angiogenic performance and blunts the myofibroblast-like profibrotic phenotype of SSc-MVECs, thus providing new evidence for repurposing sGCSs for SSc. |
Toll-like receptor triggering in systemic sclerosis: Time to target. The presence of DAMPs in association with fibrosis has been highlighted. Given their prominent role in disease this review discusses the evidence of their expression and role in disease pathogenesis and discusses possible therapeutic intervention to mitigate fibrosis. |
Women in rheumatology: major contributions and key discoveries of the XX century. In this article we acknowledge key scientific discoveries and major contributions made by 20 brilliant women scientists that shaped the field of rheumatology in the XX century. We hope that achievements of these remarkable women will inspire young rheumatologists and researchers. |
Work situation, work ability and expectation of returning to work in patients with systemic autoimmune myopathies. Our findings highlight the poor work participation in a well-characterized sample of working-age patients with SAMs. Strategies to improve work-related outcomes in these patients are urgently needed. |
Plenty of the editorials are available as full text through the publisher website using the provided link
| Arthritis Care Res (Hoboken) |
| Arthritis Res Ther |
Senescence in osteoarthritis: from mechanism to potential treatment. Risk factors for OA are ageing, obesity, metabolic disorders and mechanical overload. Determining the relationship between known risk factors and senescence will help elucidate OA pathogenesis and identify optimal treatments. |
| Arthritis Rheumatol |
Letters to the editors and authors’ replies
all remaining publications eg case reports, images of the month, etc…
| Rheumatology (Oxford) |